Monday, February 17, 2020

The latest attempt at an HIV vaccine has failed, as researchers announced Monday they have stopped giving the experimental shots in a major study. The study had enrolled more than 5,400 people since 2016 in South Africa, a country with one of the world’s highest HIV rates.

Last month, monitors checked how the study was going and found 129 HIV infections had occurred among the vaccine recipients compared with 123 among those given a dummy shot, according to the US National Institutes of Health.

“An HIV vaccine is essential to end the global pandemic and we hoped this vaccine candidate would work. Regrettably, it does not,” said NIH infectious diseases chief Dr Anthony Fauci.

There were no safety concerns, but NIH, which sponsored the study, agreed that vaccinations should stop.

The experimental shot was based on the only vaccine ever shown to offer even modest protection against HIV, one that was deemed 31% effective in Thailand.

That wasn’t good enough for real-world use but gave scientists a starting point.

They beefed up the shot and adapted it to the HIV subtype that’s common in southern Africa.

Two other large studies, in several countries, are under way testing a different approach to a possible HIV vaccine.

February 16, 2020  AUCKLAND, New Zealand (AP) — An emotional Elton John had to cut short a performance in New Zealand on Sunday after he lost his voice due to walking pneumonia and had to be assisted off stage. John reached out to his fans on Instagram on Sunday, apologizing for ending his show at Auckland’s Mt Smart Stadium early. “I want to thank everyone who attended tonight’s gig in Auckland. I was diagnosed with walking pneumonia earlier today, but I was determined to give you the best show humanly possible,” he wrote. “I played and sang my heart out, until my voice could sing no more. I’m disappointed, deeply upset and sorry. I gave it all I had. Thank-you so much for your extraordinary support and all the love you showed me during tonight’s performance. I am eternally grateful. Love, Elton xx”

February 2, 20202  MIAMI (AP) — Descending from the air, Lady Gaga kicked off a pre-Super Bowl concert by mimicking her entrance to her Super Bowl halftime performance three years ago, which earned her rave reviews. Headlining the big sports stage was a recurring theme of her Miami concert Saturday night, and the pop star sent a message to Sunday’s featured performers: “I better hear no lip-syncing tomorrow!” Jennifer Lopez and Shakira will join forces to perform at Super Bowl 54 at the Hard Rock Stadium, when the San Francisco 49ers will take on the Kansas City Chiefs.

MIAMI (AP) — Fat Joe brought New York hip-hop to Miami for an energetic pre-Super Bowl concert a day ahead of the big game. The Bronx rapper was joined by fellow New Yorkers 50 Cent and Remy Ma for the Pepsi Super Splash Pool Party on Saturday at Clevelander South Beach. Joe performed a number of hits, including the Grammy-nominated smashes “What’s Luv?,” “Lean Back” and “All the Way Up.” Ma surprised the audience, rapping on the latter two songs, while her rapper-husband, Papoose, freestyled onstage, earning cheers from the crowd. 50 Cent, who is from Queens, got the loudest applause from the hyped crowd when he performed “What Up Gangsta” and his debut hit, “In Da Club.”

MIAMI (AP) — Vin Diesel says it’s the spirit of Paul Walker that motivates him to continue starring in the “Fast and Furious” saga. Diesel and the cast spoke of the memory of their late screen partner at a special event surrounding the upcoming release of the franchise’s ninth chapter, “F9: Fast and Furious 9.” The recent death of Kobe Bryant reminded Diesel of the loss of his friend. “I can’t make a ‘Fast’ without Pablo in my thoughts, in my everyday activity, in my approach to every scene,” Diesel said, invoking his affectionate nickname for Walker. “His spirit must live in this saga, because his spirit, in so many ways, is what drives me to continue the saga.”